Some time ago I was asked about how to work with He3 neutron detectors while doing a fusion research with many kilovolts equipment near neutron detectors. We know that proportional neutron detectors generates around only 0.1-0.3 pC charge per detected neutron, and this becomes a problem, also ground loops in all equipment adds their input to overall interferences.
I have made the experimental electronics for He3 counter readout with a very compact design: all HV and charge amplifier arranged near the anode terminal of He3 counter, and all transmission of the resulting signal is carried out using balanced circuit. Standard cheap USB C to C cables can be used, and immunity to external interference is very high. I tried to discharge 1000 pF ~15 kV and sparks was ~15-20 mm long near the signal cable with no visible interference with the signal.
[assistant, slides!]
HV part and charge amplifier. HV part is veru compact because of ~300 kHz sinewave resonant converter, very small capacitors needed to filter out all the ripple.

HV part and charge amplifier assembled together. No. it's not my hand too big, it's M2.5 standoffs instead of M3. All electronics fits inside 30 mm tube.

Mating part which converts balanced signal to unbalanced and eliminates any possible ground loops with DC-DC converter

Resulting signal, ~0.15 pC per volt

That's all for today :)